Letter to the editor of the Journal of the American College of Emergency Physicians. Newman, R. and Jagannadha Sastry, K. (2021). JACEP Open, 2: e12469.
Our recent research with oleandrin as a proposed inhibitor of SARS-CoV-2 has demonstrated that low nanomolar concentrations of this molecule achieved near-total inhibition of the relative infectivity of this virus. The effective antiviral oleandrin concentrations were a fraction of that required for the control of cancer cell lines. This suggests that the use of oleandrin or a properly defined extract containing this molecule could be used to control COVID-19 without toxicity.
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