Oleander attenuates hepatic inflammation in a TLR4-independent manner and by favorable modulation of hepatocellular global metabolome that supports cytoprotection
January 9, 2024
Priyankar Dey, Nisha Tewari, Somit Dutta, Robert A. Newman, Tapas Kumar Chaudhuri
Journal of Ethnopharmacology, Volume 323, 2024, 117717, ISSN 0378-8741
https://doi.org/10.1016/j.jep.2024.117717
Nerium oleander (NO) has been traditionally used in medicinal systems across the globe to treat liver-associated chronic metabolic diseases. This article reports the results of an investigation into the cellular mechanisms involved in the hepatoprotective effects of a non-toxic dose of oleander. NO reduced systemic inflammation, serum lipid peroxidation byproducts, and glucose levels while also attenuating inflammation-induced loss of antioxidant enzyme activities. Importantly, the research found that NO favorably modulates the intracellular global metabolome (key metabolic pathways) that support cytoprotective activities.
